Sildenafil is developing by Pfizer (known as Viagra by Pfizer). Sildenafil prevents cGMP-specific (cyclic guanosine monophosphate) phosphodiesterase type 5 (PDE5), which normally prevents cGMP cavernosal. cGMP has the cavernosal arteries broad impact. cGMP cavernosal volume is increased when sexual arousal will be released cavernosal nitric oxide (NO) the parasympathetic nervous system activation time. The nitric oxide bound to receptors, cGMP when the number is increasing. Sildenafil is rapidly absorbed after oral administration and its bioavailability is approximately 40%.
It is metabolized primarily in the liver by cytochrome P450 3A4 enzyme to an inactive metabolite, which has the same effect as sildenafil. P450 3A4: AA inhibiting drugs (such as erythromycin and ketoconazole) increase the plasma concentrations of sildenafil, including cimetidine increased plasma concentrations of sildenafil. It is including the elderly, plasma concentrations rise higher. Sildenafil and its active metabolite are about four hours. Sildenafil is excreted as metabolites predominantly in the faeces, to a lesser extent in the urine. The dose is 25-100 mg. Onset of about -1 hours, and lasts about four hours. If the dose has taken a big meal, take a longer onset. Sildenafil should not be used more than once a day. To get the complete viagra articles, always-health.com is the site that you have to visit.
Mark Sisson, over at one of my favorite sites, recently wrote a post called Grok Tag. It is so well written because his description of recess is "spot on". I lived for recess back in Elementary School! It was a blast. I remember basically doing all activities full throttle and having fun no matter what we were doing. This article is not a tip or anything like that. I just wanted to back Mark's message from his recent post.
[I will never be too old to enjoy a great rope swing! I need to find a great one this summer...and a good place for cliff diving. This stuff never gets old!]
I Have a Love-Hate Relationship With Technology!
I like the Internet, the convenience of cell phones, On Demand TV and things like that…but it make me a little sad that kids are missing out on a lot of playing outside. When I was a kid video games were around, but they weren't such a major focus. I typically played outside until I dropped and then would occasionally play a video game maybe 1-2 times per week. Oh yeah…and I was fine going through the day without constantly having to hear my favorite music. Am I sounding old?
Dodgeball, Waterballoon Wars, BMX Riding, etc.
I heard that kids aren't allowed to play dodgeball anymore. I think we had 4-5 different types of dodgeball (Free Dodge Ball, Indian Doge Ball, Soak Em', etc). If I was in charge dodgeball would be encouraged in all schools (maybe not mandatory). Many other rowdy activities are now discouraged at school. We played a game where a football would get thrown up in the air and whoever caught it was a target to get tackled by the mob of kids. Another game was playing soccer and whoever was dribbling the ball would be a target for everyone to "slide tackle". Slide tackling was BIG when I was in 4th-6th grade!
Mark's Post Reminded ME of How Much Energy We Had!
There were a lot of games that involved full-blown sprinting back then. Tag was one of the games that really got kids sprinting. I talk about "HGH Flush" on this site (being short of breath, skin gets red and hot to the touch). Tag creates a huge HGH Flush! I love the energy that Tag creates especially when you are being chased. For some reason you can push past the pain barrier when you are trying to escape.
Tag is NOW Getting Banned in Schools!!!!
Pretty soon they are going to be cutting rope swings down! I am sad and a little angry. I am going to support Mark's message about "letting kids be kids". Please head on over to his site and read his outstanding article on the subject—>Grok Tag . Mark has actually designed a workout that involves Tag, Burpees, and Pushups. This is thinking outside of the box and is probably one of the best blog posts I have read in a long time.
Note: I have been posting a little less than normal lately…I will do my best to increase the amount of posts. I'm just finishing up on a project that is taking a lot of my time right now.
Tags: Main, HGH, HGH flush, mark sisson, marks daily apple, Video Games, workout
Forget the phrase “You are what you eat.” Now it’s “You are how much you eat.”
At least that’s the message given by the new Gluttony Pants, designed (with a sick sense of humor) by San Francisco-based chef and former Iron Chef contestant Chris Cosentino for Betabrand. Gluttony Pants are made with three buttons on the waist to allow for more, how shall I say, wiggle room in your eating experience.
In other words: How piggy are you feeling today?
Each button has an embroidered label for the level of how much “pigging out” you’re in the mood for.
If you’re just planning a minor binge, use the “Piglet” button. Wanting to reject any sense of a diet? Go for the “Sow” button, or worse, the “Boar.” The trousers come with a coordinating burgundy napkin in case things get messy.
As a gag gift or a good conversation piece, these adjustable-waist pants can’t go wrong (though the $100 price tag makes them a bit pricey for white elephant gift exchanges).
But if you’re contemplating the practicality of the one-size-fits-all-appetites pants, you may want to stay far away from this gluttonous garb — and consider your state of mind before next stepping up to the feeding trough.
Students commencing medical school and master’s of medicine program at Stanford this year will all get an Apple iPad. The school is trialing a program to see whether the devices are practical to integrate into the academic curriculum.
Before you dismiss this as medical education being sacrificied in the name of fanboy hype, consider this — when some of our editors were in medical school, the semesterly (mandatory) fee for handouts and photocopies was about the cost of a lower-end iPad. And that was years ago. We can only imagine the charges now. So moving the medical education culture of endless handouts and notebooks over to a compact tablet device could be very smart. More from Stanford officials:
The decision to provide the devices was prompted by a desire to give students flexible access to the content that they need whether it is a virtual cadaver in dissection lab, annotated lecture slides and videos in the classroom, or journal articles for evidence-based practice in clinic.
“We want to explore the use of iPads and other technologies to help students access the enormous amount of medical knowledge that is being produced constantly,” said Charles Prober, MD, the school’s senior associate dean for medical education. “Part of the challenge facing medical students, and all doctors, is the overwhelming amount of information. Devices like the iPad may be able to help users access that pool of knowledge.”
The school will monitor the use of the iPads through regular surveys to help determine how helpful they are to students, pointing out that past experiments with similar electronic devices, such as the Kindle, in academic settings haven’t been successful.
“We really don’t know yet how the incoming medical students will use them,” said Henry Lowe, MD, senior associate dean for information resources and technology. But, as a physician using an iPad himself, he’s found the device to be extremely helpful and believes it is growing in popularity among doctors.
“Physicians are a mobile group,” Lowe said. “They’re moving around from clinic to clinic, from patient to patient. … I’ve seen a variety of reports from across the country saying that physicians have seized on the iPad as a helpful device.”
Press release: iPads to be distributed to incoming class by Stanford medical school …
People who have trained in the gym for years often look at something like the simple push up as a beginner's exercise. I mean, why would they want to perform push ups when they can get a "real" chest workout with heavy sets of bench presses. This is a big mistake, and one that I have been guilty of. It is easy to look at the simple push up as working the exact same muscles as the bench press, but with less resistance. I would like to talk about why you should include the push up in your routine, even if you are someone who trains with free weights.
[Here are a few guys "benching" on the edge of the River Thames in London using decent form. Yes...a bad joke, but better than the typical bench press article picture...a bulky guy in a lifting suit bench pressing a ton with his face as red as a beet.]
What I Never Knew About Push Ups
Before I talk about the push up, I'd like to give thanks to Chris over at Conditioning Research for linking to a great article. I've said it many times on this site, but it amazes me about how Chris stays on top of all of the recent info in the Fitness industry. His site is outstanding and I would recommend subscribing to his RSS feed. What I want to do is link to the same article, but just highlight some of the points I find interesting. I'll also include a few video clips and then lets discuss this in the comment section. Here's the full push up article: What You Dont Know About the Push-up.
Push Ups Balance Upper Back Strength With Chest
Ever see a guy who benches too much and his shoulders are pulled forward? Or a guy with large pecs and bad back development? Well, push ups can work the upper back in ways that a benching cannot. The scapula is allowed to go through a full range of motion with push ups, but is constricted in all forms of bench pressing. When the scapula goes through its full range of motion with push ups, it fills in the area in between the shoulder blades (upper and lower trap thickness). It also develops the serratus muscle, which frame the lower chest and abs to a certain extent.
The Most Important Part of the Push Up
Ever hear this saying…"you don't know what you don't know"? I had no idea that the very top of the push up was the most important part. The scapula won't fully contract until the elbows are all the way locked out. What you need to do is push to lockout and then make sure your upper back isn't sagging down at the top. Here is a video of Zach Dechant showing proper form.
[So the lockout is important. Notice how his upper back isn't sagging downward. You want to continue to push shoulders towards the floor even at the top of the movement.]
Push Ups for Better Abs and Obliques?
So I knew that push ups worked the abs in a way that is similar to planks. Here is what I didn't know… According to Jeffrey McBride, push ups work the obliques better than side bridges. So not only do push ups work the serratus muscles, they work the obliques extremely well. These are the muscle groups which "frame" your abs. Here is a highly scientific, textbook style diagram…
[Most of us are lagging in a bit in this area. Push Ups will help tighten up this part of your midsection. Another good exercise if you want to tighten up your obliques is Renegade Rows (link to an article on this blog).]
Do You Like to Throw Things?
…well push ups will also work your "throwing muscles" much better than the bench press. This works for any sports that involve throwing…football, baseball, softball, etc. Go over and read Zach's article because he goes over this in detail. Zach is a coach at TCU for both baseball and football. Here is his stance on push ups with athletes who throw…"At TCU, our baseball athletes and quarterbacks incorporate some form of the push-up year round in their training. At various times, we even eliminate all forms of pressing in lieu of the push-up and its many variations."
How to Make the Push Up More Challenging
Obviously one way to make the push up quite a bit more challenging is to do them with one arm. I have a whole post dedicated on mastering the one arm push up, but these work the muscles in a different manner than using two arms. Here are some videos demonstrating a few ways to make the two-arm push up more challenging.
Walkover Push Ups
[Stack two Olympic plates. Start with one hand on the floor, perform a push up and then walk across the plates and perform another push up. Extend all the way to the top before walking across the plates. Beginner start with 5 reps and will work up to 10+ per side. This exercise really works the scapular area (around the shoulder blades).]
Chain X Push Ups
[Criss-Cross chains on your back and perform regular push ups. You can use longer chains where a lot of the weight is on the floor at the bottom. There will be an increasing amount of resistance as you get closer to the top, as more chain links will get pulled off of the floor. The greatest resistance will be at the top of the movement. This strength transfers well if you want to increase your numbers in the bench and military press.]
Explosive Push Up Jumps
[Zach believes these to be the best serratus exercise by far. These are to be done for high reps. The reason you want a band to assist is that you are aiming to do most of your pushing towards the top of the movement. When you simply do explosive push ups, most of your effort it at the beginning of the movement. When done properly, Zach claims your serratus will be worked so intensely that it will feel like you have broken ribs the next day. Obviously he doesn't mean that literally, but you get the point.]
Lateral Band Push Up Walks
[This one is the better for mid-back and shoulders than any of the other push up variations, because you have to continually spread the band. I haven't done these yet, but they look awesome. You put a light ankle band around the wrists, take 3 lateral steps and perform 1 push up. Take 3 more lateral steps and perform another push up. Begin by aiming to get 5 push ups per side for a total of 10. I can see how this would quickly make your entire upper body thicker due to working both your chest, delts and mid back so well, all in the same exercise.]
So Include Push Ups for Full Upper Body Development
Again…this is yet another example of how body weight movements work a larger group of muscles than similar free weight lifts. I still plan on lifting with free weights due to the fact that you can overload specific muscle groups, but will supplement them with more body weight movements. Also, those of you doing TACFIT or other body weight routines are probably getting a much more complete workout than it would first appear.
Check Out Zach Dechant's Blog…
The first link is a guest post he put up on another site. His personal blog is here: Zach Dechant Sports Performance Training. I have never communicated with Zach, but appreciate the content he has so far on his site. He is a conditioning coach for baseball & football, at TCU. Really good info, especially for those who are interested in improving in "throwing sports". Stop on by his site for some innovative training tips…not anything like the typical fitness info you have heard a zillion times.
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Tags: Strength Training, bench press, free weights, high reps, military press, muscle groups, planks, push ups, renegade rows